Therapeutic protein production in chicken eggs
Researchers at the Roslin
Institute, Scotland, have successfully bred five generations of transgenic hens
producing therapeutic proteins in the whites of their eggs.
Researchers have reported the
successful production of two drug candidates in the eggs of these transgenic
The organisation is working with
Oxford BioMedica and Viragen to develop their avian transgenic system as a
large-scale biomanufacturing alternative for a variety of proteins.
Alan Kingsman, CEO of Oxford
BioMedica: â€This technology could address a substantial need in the
biopharmaceutical industry for efficient, high-volume production of biological
It has previously been estimated
that a small flock of a few hundred hens could satisfy the entire US market
demand for interferon beta-1a.
â€We are very pleased that the
PNAS article chronicles our 'proof-of-principle' studies resulting in successful
germline transmission of two therapeutic proteins,â€ said Viragen vice president, Karen Jervis.
The research is published in the
Proceedings of the National Academy
of Sciences (PNAS).
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