Scientists create Avian Flu vaccine with monkey cells
Using the cells of monkeys instead of chicken eggs can make an effective
vaccine against pandemic avian flu, reports the New England Journal of Medicine.
Vaccines to protect people against a highly virulent
H5N1 bird flu pandemic are made using the embryos of hens' eggs. "Although
it is the best we have, for the long term it's probably not" explained Peter
Wright, a professor of pediatrics at Dartmouth College in Hanover, New
Hampshire.Not enough doses
Wright says because chickens lay
most of the eggs in the spring the vaccine production method, which was
developed a half century ago, limits how many doses can be produced.
eggs are used to grow the virus to make the vaccine that prompts the immune
system to target the disease. Writing in the New England Journal of Medicine,
Wright says an experimental vaccine that's produced using monkey cells begins to
address some of the problems with the current stockpiles of avian flu vaccine.
Using primate cells
Hartmut Ehrlich, who is with Baxter
Bioscience in Vienna, Austria and is the study's lead author, says using primate
cells to make the vaccine could significantly reduce the amount of time it takes
to manufacture the vaccine. "That means from the time we and other
manufacturers are getting the pandemic strain for producing the vaccine it will
take us about 12 weeks less," he noted. "So that translates into three
months to have vaccine ready to ship out."
In a clinical study involving
275 individuals, the two-dose vaccine protected p to 76 percent of the
participants after 21 days. Ehrlich says other experimental H5N1 vaccines
are not as protective. Meanwhile, global health officials remain concerned that
millions of doses of avian flu vaccine that have been stockpiled for years in
anticipation of a bird flu pandemic are beginning to lose their
potency. Officials are calling for adjuvants, or additives, to be set aside
to strengthen the vaccines.Subscribe here to
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